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100			_aGoldman Nick
245		0	_aTowards practical, high-capasity, low-maintenance information storage in synthesized DNA
260			_bNature _c2013
300			_a77-80
520			_aDigital production, transmission and storage have revolutionzed how we access and use information but have also made archiving an increasingly complex task that requires active, continuing maintenance of digital media. This challenge has focused some interest on DNA as an attractive target for information storage because of its capasity for high dencity information encoding, longevity under easily achieved conditions and proven track record as an information bearer. Previous DNA based information storage approaches have encoded only trivial amounts of information or were not amenable to scaling-up, and used no robust error-correction and lacked examination of their cost-efficiency for large scale information archival. Here we describe a scalable method that can reliably store more information than has been handled before. We encoded computer files totalling 739 kilobytes of hard-disk storage and with an estimated Shannon information of 5.2x10raised to6 bits into a DNA code, synthesized this DNA sequenced it and reconstructed the original files with 100;accuracy. Theoretical analysis indicates that our DNA-based storage scheme could be scaled for beyond current global information volumes and offers a realistic technology for large-scale, long-term and frequently accessed digital archiving. In fact, current trends in techological advances are reducing DNA synthesis costs at a pace that should make our scheme cost-effective for sub-50-year archiving within a decade.
650			_aDNA
650			_ainformation storage
700			_aBertone Paul
700			_aBirney Ewan
700			_aChen Siyuan
700			_aDessimoz Christophe
700			_aLeproust MEmily
700			_aSipos Botond
942			_cJS
999			_c71416 _d71416