000			01516nam a2200205Ia 4500
008			220216s9999 xx 000 0 und d
100			_aNakede S
245		0	_aStudies of high purity natural rubber (V): Provisional guidelines on the design of latex allergy free NRL products
260			_bInternational Polymer Science and Technology _c1998
300			_aT29-T32
500			_aSource Year: 1998
520			_aPrick test studies of raw materials and products of commercial natural rubber latex and highly deproteinised natural rubber latex showed different threshold levels of residual extractable protein. Allergenic activity must also take account of the nature of the allergenic proteins; the problem cannot be referred solely to the amount of extractable protein. The threshold level for NRL products is currently 50-100 ng/g, a level impossible to attain by leaching out the protein content. The proteolytic effect of enzymes has a considerable impact. In HDPNRL products the threshold level is relaxed by a factor of 600, taking the threshold to 30-40 ug/g and the allergen free requirement is easily attained. One way of eliminating latex allergy would be to add a purpose-designed proteolytic step to the NRL product manufacturing process. It is recommended that this or a similar process be introduced to decompose the protein contained in NRL.
700			_aBito T
700			_aHayashi M
700			_aIchihashi M
700			_aOkada J
700			_aTanaka Y
856			_uIRRDB
942			_cJS
999			_c69523 _d69523