000			01715nam a2200205Ia 4500
008			220216s9999 xx 000 0 und d
100			_aRahimi A
245		0	_aReview on rubbers in medicine: natural, silicone and polyurethane rubbers
260			_bPlastics, Rubber and composites Macromolecular Engineering _c2013
300			_a223-230
520			_aNatural, silicone and polyurethane rubbers are considered as three important biomaterials which have found widespread applications in medical technology. Biocompatibility, biodurability, sterilisability, processibility, as well as mechanical properties, such as flexibility and resilience, are properties that make these kinds of rubbers appropriates candidates for mechanical applications. Medical devices based on natural rubber, silicone and polyurethane rubbers include cardiac pacemaker leads, mammary prostheses, artificial skin, catheters, denture liners, diaphragms, blood pressure cuff coil, tubes and seals. These type of rubbers are commonly used in controlled drug delivery systems as a carrier for phaemaceutical agents and in the fabrication of other medical devices.These polymers were evaluated for release of hormones (e.g. estradiol and progesterone), metronidazole, nonoxynol-9, etc. In this paper, some recent advances on the development of these polymers in the biomedical field and some reports on the modification and improvement of their properties such as drug release and mechanical properties are reviewed.
650			_aBiomaterial
650			_aBiomedical devices
650			_aDrug delivery systems
650			_aNatural rubber
650			_aPolyurethane
650			_aSilicone rubber
700			_aMashak A
942			_cJS
999			_c66968 _d66968