000			01773nam a2200157Ia 4500
008			220104s9999 xx 000 0 und d
100			_aChaocai Tang
245		0	_aMechanism of hypolipidemic effect of rubber seed oil- Its effect on cholestrol tolerant test in rhesus monkey
520			_aRubber seed oil is one of the plant oils rich in polyunsaturated fats. We have demonstrated that it has some hypolipidemic effects both in experimental hyperlipoidemic animals and in hyperlipoidemic patients. The present study was performed on 30 Rhesus monkeys (Macaca mulatta) which were divided in to four groups. Group 1, received lard (20 ml) and cholestrol, Group 2, rubber seed oil (20 ml) and cholestrol (2 g), Group 3, R-PuF ( 20 ml) and cholestrol ( 2 g), Group 4, normal saline ( 20 ml) alone. Following the overnight fasting, the blood samples were obtained for total cholestrol (T-ch) , triglyceride (TG) and high density lipoprotein cholestrol (HDL-ch). T-ch, TG and HDL-ch levels were determined repeatedly at 1, 2, 4 and 8 hours after the administration of a single dose of oral drugs. The results showed that following the administration of a single dose of drugs, the T-ch peak level was higher in Group 1 than in Group 2 and 3, but the blood T-ch level decreased more rapidly in Group 2 and 3 than in Group 1. In addition, lard was able to decrease HDL-ch level two hours after the administration of a single dose while rubber seed oil and R-PuF were able to increase it at the same time. These results suggested that R-PuF might be a main hypolipidemic component of rubber seed oil.
650			_aCholestrol tolerant test
650			_aHypolipidemic effect
650			_aRhesus monkeys
650			_aRubber seed oil
700			_aZhixiong Zhang
942			_cBE
999			_c47405 _d47405