Rubber is the second most important export crop in Cote d’Ivoire, making it the leading natural rubber producing country in Africa with a production of 1,100,000 tonnes. Despite this performance, rubber cultivation is under threat from Corynespora leaf fall disease (CLFD) caused by Corynespora cassiicola. In order to find a way to control this disease, a study was undertaken to assess the situation of C. cassiicola attack in the Ivorian rubber sector and to develop a control strategy against this leaf disease. It consisted of conducting a phytosanitary survey in the rubber plantations of all rubber growing sectors. The results revealed the presence of CLFD in 14 of the 18 rubber sectors surveyed. The Grand-Bereby sector recorded the highest incidence rate, with 22.60% of plantations affected, followed by the Soubre, Dabou and Bettie sectors with attack rates ranging from 16 to 9%. The remaining 14 sectors recorded disease incidence rates of less than 3%. The results of the survey also showed that plantations of the GT 1 and IRCA 18 clones were the most affected by the disease with incidence rates of 15 and 14% respectively. In finding a control strategy for this disease, the susceptibility of 23 rubber clones was evaluated in the graft wood garden. The results showed a fluctuation in the susceptibility of the rubber clones over the last five years. However, three clones, namely PB 217, IRCA 101 and IRCA 538 expressed a good level of resistance to this disease during the five years of observation, unlike the susceptible control IRCA 18 which confirmed its high susceptibility to this disease. A comparative test of fungicide treatments using a sprayer and/or a drone was also conducted. The results obtained after four applications of the fungicide (Carbendazim 100 g/l + Chlorothalonil 550 g/l), at a dose of 2 litres per hectare, showed a good level of efficiency of the fungicide treatments with the drone and the drone + sprayer combination. The sprayer is suitable for treating immature plantations, while the drone is suitable for all types of plantations, especially those with trees over 14 m of height.