Natural Rubber (NR) is an important commercial commodity sourced from Para rubber tree Hevea brasiliensis.NR is being used for making variety of products in automobile and health industry. Most of the present Hevea cultivars in India are susceptible to leaf disease caused by Corynespora cassicola. Chemical control of Corynespora Leaf Disease (CLD) is accomplished through aerial spraying of chemical fungicides, which is harmful to the ecosystem and increases input costs of cultivation. In the present study, we have developed new recombinants through either cross breeding and half sib selection approach. The clonal progenies are being evaluated in a field trial for the important primary traits and CLD tolerance. CLD tolerance was assessed using in vitro leaf wilt scoring method as well as field screening. Selection of clones was done based on the superiority in growth, dry rubber yield and disease tolerance. Elite clones such as 683 (PB 330 x RRII 414) was identified from the population. Most desirable genotypes with demonstrated vigorous growth, yield and disease tolerance when compared to check/parental clones such as RRII 105, RRII 414, RRII 429 and PB 330 was selected. The study also demonstrated that the in vitro screening method using CLD toxin could be a rapid first level screening tool against CLD across genotypes for identification of inherent genetic variability and selection. These approaches could reduce the burden of screening larger breeding population to a manageable size to enhance the efficiency of selection and augment disease resistance breeding programs of Hevea for CLD. Selected fast growing, high yielding and CLD tolerant candidate genotypes which could be further evaluated in on farm trials for recommendation to the growers in the traditional region of rubber growing tracts. The selected genotypes would enrich the breeding pool to achieve high yielding CLD tolerant recombinants.