The antagonistic activity of 77 bacterial isolates collected from the rhizophere and non rhizosphere soil and tissues of different clones of rubber was tested against the five major pathogens of rubber, viz.Phytophthora meadii, Corynespora cassiicola, Colletotrichum acutatum, Corticium salmonicolor and Phellinus noxius by dual inoculation and selected five isolates showing larger zone of inhibition of each of the pathogens. Pseudomonas spp. and Bacillus spp. were the main antagonistic bacterial group which included the endophytes and rhizophere colonizers. They produced various antipathogenic and plant growth promoting metabolites. The compatibility of the antagonists with four systemic fungicidesviz.tridemorph (Calixin), hexaconazole (Contaf), Propiconazole (Tilt) and carbendazim (Bavistin) and two contact fungicides viz. mancozeb (Indofil M-45) and wettable sulphur (Sulfex) commonly used in rubber plantations was studied at different concentrations under in vitro conditions. Carbendazim was the only systemic fungicide tested which was safe to all the isolates studied. The contact fungicide mancozeb was inhibitting the growth of all the antagonists even at the lowest level studied while wettable sulphur was not harmful to most of the isolates even at double the recommened level. Pseudomonas app. in this study were more tolerant than Bacillus spp., to the fungicides used inrubber cultivation.