Relevant developments in polymer blends on immiscible polymers have shown how efficient the amphiphilic species are in improving mechanical properties and morphological stabilisation through reactive and dynamic vulcanisation on successive processing steps. However, it appears that, in blends of immiscible polymers, the interfacial compatibilities of polymers are necessarily mixed before the dynamically vulcanised process to obtain good mechanical properties of thermoplastic elastoemrs. The induced reactivity in a single screw extrusion is based on a misture of peroxide (Perkadox 14@), reactive monomer (maleic anhydride) and activators (ZnO and stearic acid). The results confirm that a good level of reciprocal grafting occurred between NR and PA6. Their morphology showed a good interfacial adhesion with finer continuous phase of PA6. Dynamically vulcanised processes were done using several vulcanising systems on a single screw extruder. It showed that the suitable vulcanising agent was phenolic resin (SP-1045). The produced thermoplastic elastomer showed a fine crosslinked dispersed phase NR, which corresponded to good mechanical properties of high tensile strength and elongation at break. The PA6/NR reactive blend TPE containing PA6 40;and NR 60;had a tensile strength level about 12MPa with the elongation at break about 135;. It also showed very good oil resistance at an ultra-high temperature of 200 oC.