Weed infestation is a major problem during the early stages of establishment of rubber forest plantation. Currently, information on effective weed control system in young rubber forest plantation is limited. As the rubber forest plantation is often located in remote areas, a weed control system which provides longer duration of weed control is preferred. Trials were conducted to determine effective rates of glyphosate isopropylamine and its mixtures against mixed weeds. Glyphosate isopropylamine at 1.08 kg ae/ha mixed with metsulfuron methyl (0.03 kg ai/ha), fluroxypyr (0.3 kg ae/ha), dicamba (0.6 kg ae/ha) or premixed picloram + 2,4-D(0.097 kg ae/ha + 0.36 kg ae/ha) were effective. Glufosinate ammonium at 0.9 kg ae/ha gave shorter duration of control against mixed weeds compared to glyphosate (1.08 kg ae/ha) + metsulfuron methyl (0.03 kg ai/ha). Glyphosate isopropylamine (1.08 kg ae/ha) + metsulfuron methyl (0.03 kg ai/ha) at two or four rounds per year provided more effective weed control than slashing. Slashing at two or four rounds was ineffective and at two rounds per year gave rise to serious weed regeneration.