Corynespora leaf fall (CLF) of rubber, a disease with relatively a recent origin has now identified as a serious limitation to the production of natural rubber which brings comfort to consumers world wide. Except China all leading rubber growing countries in Asian and African continents suffer from this disease. During its worldwide epidemic in mid 1980s two prestigious clones, RRIC 103 and RRIM 725 have been wiped out from the major rubber growing countries. Since then it has become a grave threat to the worlds natural rubber industry attacking several outstanding clones namely RRIM 600, RRII 105, AVROS 2037, PB 260, RRIC 110, GT 1 and IAN 873 which have been considered as resistant or moderately resistant during the first epidemic. Although hundreds of different genetic materials have been offered by the Breeders, only a handful of clones namely; RRIM 600, GT 1, RRII 105, PB 260, AVROS 2037 and PB 86 dominate the cultivated rubber lands in the world. The apparent sudden susceptibility of most of the leading clones which contribute to more than 60;of the worlds natural rubber production has raised the concern over the future development of the rubber plantation industries in both African and Asian continents.